Google CEO Eric Schmidt gave what he just had to know would be a much quoted comment to the Nikkei today, explicitly saying that the company had “begun seriously looking into acquisitions again.”

Music to the beleaguered mergers and acquisitions market, to be sure, especially after a recent uptick from other big companies pulling out their wallets again as the impact of the econalypse subsides.

According to sources, Google is working on at least a half-dozen acquisition deals, most of which are small start-ups in the online advertising and cloud-computing arenas.

That would be welcome news for many.

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Last night, onstage at Lincoln Center in Manhattan, my most excellent partner, Walt Mossberg, interviewed well-known techno musician Moby about music and entertainment in the digital age.

The wide-ranging talk was part of an ongoing cultural festival series organized by The Wall Street Journal, called Summer Scoops Live.

Here are some video clips of the event and more.

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One of the first Silicon Valley start-ups to go public in a long while–OpenTable–is expected to come to market this week, with venture firms hoping it will prove a tasty treat for Wall Street.

Whether the $42 million initial public offering of the online restaurant reservation service proves to be a bellwether or not is unclear since its business has–despite strong revenue gains over the last two years–run up operating losses for much of its lifespan of more than 10 years.

In any case, OpenTable is most definitely a creature of Silicon Valley. Its CEO, Jeff Jordan, is a former top eBay exec, and one of its VC backers is Benchmark Capital, among others.

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Incredibly, this is the seventh year of the D: All Things Digital conference.

We feel very lucky to get here, especially in the midst of what our own site’s Digital Daily scribe, John Paczkowski, has so perfectly dubbed the “econalypse.”

Ironically, Walt Mossberg and I planned to launch the very first conference in the middle of the last major downturn for tech, in 2001. But, in the carnage of the Web 1.0 meltdown, we actually held off for two years, with our first D gathering taking place in 2003.

Well, we’re still going–making the same long-term bet that the digital revolution will keep rolling as we did at D1. Here’s our lineup for D7.

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More musical chairs at Yahoo, which BoomTown predicted recently, as top execs at the company move in and out of jobs, and new ones from the outside move in.

Perhaps the most important change to occur is the replacement this week of SVP Scott Dietzen–who had been in charge of all communications and communities products at Yahoo–by former Adobe Systems exec Bryan Lamkin, several sources said.

And there’s even more…

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Last week, StumbleUpon announced it was buying itself out of its much-vaunted previous corporate buyout, by being born again as an “investor-baked start-up.”

The Canadian-born social-bookmarking company, which was launched earlier, came to the Bay area in 2006 and got some fancy venture investors and soon became a traffic-generating hit.

Then StumbleUpon was bought by eBay two years ago for $75 million in one of Web 2.0’s high points.

End of a fairy tale? Um, nope.

Here’s CEO and co-founder Garrett Camp, talking to BoomTown in a video interview about it all.

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The content-discovery service, StumbleUpon, has gotten itself back to start-up status, after being bought by eBay two years ago.

It announced today that it was returning to being an “investor-backed startup” by a roster of well-known Silicon Valley investors, including Ram Shriram of Sherpalo Ventures, Accel Partners and August Capital.

Its founders, Garrett Camp and Geoff Smith, are also back, with Camp now in place as CEO.

“We are grateful to eBay for its guidance. However, we realized there were few long-term synergies between the two businesses. It is best for us to part ways and focus on our respective strengths,” said Camp, stating the very obvious.

That’s quite a boomerang since it was acquired by the auction giant in 2007 for $75 million.

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SiliconANGLE blogger John Furrier found a supersweet television ad that eBay Internet phone unit Skype is running to goose its brand.

The once-hottest-ever start-up–touted up and down Silicon Valley for its explosive growth back in 2003–is still a major global brand with a massive 405 million user accounts at the end of 2008.

In fact, Skype’s size makes media-overhyped Twitter seem, well, twee, by comparison. Twitter had only 9.8 million unique visitors in February, up impressively from 6.1 million in January.

But the hot-or-not comparisons between the two are interesting to think about.

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Late last night, Yahoo’s Tapan Bhat posted an update on the ongoing redesign of the Internet giant’s homepage, a massive undertaking given that 300 million people visit it each month.

Bhat, who is SVP of Yahoo’s Front Doors, Communities and Network Services, said the company was completing the first phase of its “bucket testing” and collecting feedback, but that, “Bottom line is we’re getting closer to the final design, but we’re not quite there yet.”

Indeed not, according to several sources at Yahoo, who said that the massive underhaul of the homepage has been a much more complex, much dicier effort and was taking a lot longer than expected to launch.

And, more importantly, new CEO Carol Bartz is also giving it the once-over.

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Here’s a video of former eBay CEO Meg Whitman talking to Matt Lauer on the “Today” show this morning about her nascent campaign to be governor of California as the Republican candidate.

Whitman, who was a favorite of failed Presidential nominee Sen. John McCain, seems to have perfected the art of saying exactly nothing, even after Lauer asked her if she was nuts to run the “arguably ungovernable”–referencing a writer for the Sacramento Bee–California.

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Many years ago in the midst of the Web 1.0 boom, when working as a reporter for The Wall Street Journal, BoomTown redubbed an annual dinner that book agent John Brockman threw at the TED conference.

It was jokingly called the “Millionaires’ Dinner,” but I renamed it the “Billionaires’ Dinner.”

That was due to the frothy fortunes that had been made at the time by the Internet pioneers, from Amazon to AOL to eBay. Get it?!?

Well, despite the economic meltdown, there were still a lot of billionaires in attendance at Brockman’s most recent dinner last Thursday in Long Beach. But he recounted to me that the proceedings were a lot more focused on the serious times we are in, as was the whole digerati-packed conference held last week.

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Over the next two weeks, tech companies will be reporting their fourth-quarter earnings and the expectations are pretty much what you might imagine: Bad to very bad to very, very bad.

That’s bad, of course, because tech has been one of the bright spots in the U.S. economy, with strong returns quarter after quarter for a long time now.

It begins today with IBM, followed by Apple, eBay, Google, Microsoft and Yahoo.

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Today, most companies in the tech and Internet sector will close the books on what is likely to be a very disappointing fourth quarter and also close out what has turned out to be a mucho depressing year, which got hammered starting in the third.

While financial results will not out for some weeks, one does not have to be a psychic to know what’s coming: A lot of weakness, with hopes for better days ahead.

It’s a far cry from how 2008 started out, with high valuations for all. Those were the days my friend, Silicon Valley thought they’d never end, to sing and dance forever and a day. As it turned out, it was more of a swan song for Web 2.0.

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With Yahoo board Chairman Roy Bostock reportedly assuring investors and others that the company will have a CEO in place by the end of the year, it seems prudent for BoomTown to initiate an official Yahoo CEO Countdown.

After all, this column had a 100-Day No-Sacred-Cows Vision Quest to mark the time that Jerry Yang said he needed to give Yahoo a top-to-bottom look-see when he took over last summer as CEO.

So here’s today’s update: No Peter Chernin and a lot of thorny issues for other candidates.

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When everyone else has been selling, it seems Carl Icahn has decided to throw good money after bad–as in nearly $1 billion bad–by buying almost seven million more Yahoo shares, according to a regulatory filing.

Why is he doing it? BoomTown is guessing that the billionaire investor thinks he can recoup some of his massive losses in Yahoo, as Jerry Yang prepares to step down and the board, on which Icahn sits, names a new leader.

That’s why my guess is that the choice of a new CEO is likely to be sooner than later, much more Icahn-friendly and strong on operational skills.

BoomTown’s new guesses: Yahoo board member John Chapple or perhaps an ops star like HP’s Todd Bradley.

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