BoomTown just got the following email from Anne Wojcicki, co-founder of 23andMe, the personal genetics start-up, about the departure of her co-founder, Linda Avey (pictured here). She will be starting a foundation related to Alzheimer’s disease.

The pair founded the high-profile company–whose Series A investors include Genentech (DNA), Google (GOOG) and New Enterprise Associates, as well as Wojcicki’s husband, Google co-founder Sergey Brin–in 2006.

It has collected almost $23 million in funding.

Avey noted in an email to staff, which is posted in its entirety below: “I also recognize that the company has reached a critical point in its growth where new leadership can take it to the successful heights we all think it can achieve.”

Wojcicki’s email reads, in part:

I wanted to let you know that Linda Avey will be leaving 23andMe to focus her energy on transforming Alzheimer’s research and treatment, leveraging the 23andMe platform. Linda and I have talked about doing research in Alzheimer’s since the inception of the company. Linda, whose father-in-law recently died from the disorder, will be leveraging 23andMe’s platform as she works to revolutionize the research, treatments and prevention for Alzheimer’s.

Linda will be greatly missed by me and my colleagues but we’re glad she will continue to be in a related field, and we are committed to continuing the work that she and I started three years ago.

And here is the email from Avey to the staff, as well as Wojcicki’s below it and then the official press release:

Dear all-

As I trust you all know, 23andMe is very special to me. I also recognize that the company has reached a critical point in its growth where new leadership can take it to the successful heights we all think it can achieve.

I’ve decided that I’d like to focus my efforts on an area that is personally significant and will continue to have a huge impact on our healthcare system–Alzheimer’s disease. Effective today, I’m leaving 23andMe and have begun making plans for the creation of a foundation dedicated to the study of this disorder. The foundation will leverage the research platform we’ve built at 23andMe–the goal is to drive the formation of the world’s largest community of individuals with a family history of Alzheimer’s, empower them with their genetic information and track their brain health using state-of-the-art tools. We’ve always planned to include Alzheimer’s in our 23andWe research mission…I’m just approaching it from a new angle.

Some of you might be aware that my father-in-law suffered from Alzheimer’s and passed away last year. For this reason, Randy and I are motivated to do what we can to improve the understanding of what leads to the debilitating symptoms and what might prevent them from starting in the first place. The ApoE4 association is barely understood but gives us a great starting point.

I’ll miss working with you but will be excited to hear about the progress I know you’ll be making!

All the best,
Linda

Team:

As Linda has told you, she will be leaving 23andMe to focus her energy on transforming Alzheimer’s research and treatment, leveraging the 23andMe platform. While I am quite sad to see her leave I am excited and hopeful as she takes on this mission. As Linda’s co-founder and partner over the last three years, it has been clear that revolutionizing research has been a primary passion. Our drive to change health care has always had roots in our personal lives and we have tried to structure 23andMe so that any individual or organization could actively participate in research. Linda and I have talked about doing research in Alzheimer’s since the inception of the company and the need for the Alzheimer’s community to have a strong leader. With Linda’s involvement, I believe that the APOE4 community could be the first asymptomatic community to successfully develop preventative treatments. I hope that going forward we’ll both be able to shake up and transform the health care space, making health care and treatments better for all.

Linda’s departure is also a sign of 23andMe’s maturation. When we started the company, the personal genetics industry did not exist; now it is a thriving and competitive landscape. Our company has grown and we continue to be an innovative industry leader. While our success has been exceptional, it is also clear we have a lot of work ahead. We have created a significant and empowering tool, but we must find new and better ways to promote the value of knowing your DNA. In the weeks ahead, we will outline a strategy for the company that we believe will make genetics a routine part of health care and will lead us to making significant research discoveries.

Linda has been instrumental in making 23andMe what it is today and we thank her for her passion and dedication to the company. We have many exciting opportunities before us, and I look forward to working with all of you to make 23andMe a spectacular success.

Anne

Linda Avey to Create Alzheimer’s Foundation

Mountain View, CA–September 4, 2009–Linda Avey, co-founder of 23andMe, an industry leader in personal genetics, announced today that she is leaving the company to start a new foundation focused on Alzheimer’s disease. Ms. Avey’s foundation will leverage the 23andMe research platform to search for causes and treatments for the disease, which afflicts more than 5.2 million people in the United States.

Ms. Avey and Anne Wojcicki founded 23andMe together in 2006. The company provides personalized genetic information through DNA analysis and allows individuals to interact with their private information through a variety of web-based tools.

“I could not be more proud of what we have accomplished in the three years since Anne and I created 23andMe, and I am excited to take the next step in applying my experiences to one of the great health challenges of our time,” said Ms. Avey, who has more than 20 years of experience in the biopharmaceutical industry. “There is a clear need for revolutionary research and concentrated effort to confront Alzheimer’s, and we need to start now in order to make meaningful progress. The resources are out there–my goal is to marshal them to find answers for families, like mine, who have lost family members to such a debilitating disease.”

Concurrent with Ms. Avey’s announcement, Ms. Wojcicki said that 23andMe expects to make its genetic data platform available to Ms. Avey’s foundation in order to advance its research.

“Linda has been a true partner with me over these last three years, an innovative leader for our company and our industry, and instrumental in making 23andMe what it is today,” said Wojcicki. “It is only fitting that she will be making full use of our work together and leveraging the 23andMe platform for a tremendous cause. We look forward to joining her as a partner in her efforts.”

Ms. Avey’s departure announced today takes effect immediately.

Here is a video, in two parts, of Avey and Wojcicki demoing some new features of 23andMe at the sixth D: All Things Digital conference in 2008.

In the first one, they introduce 23andMe, explain the main service and ask News Corp. (NWS) head Rupert Murdoch, Walt and me about our tolerance for milk and about our racing abilities. (Full disclosure: News Corp. is the owner of Dow Jones and this Web site.)

In the second one, Avey and Wojcicki survey Murdoch on his genetic traits and show me what genes my kids have in common (and discover that I am not hyperactive).

Here are the D6 demos:

More musical chairs at Yahoo, which BoomTown predicted recently, as top execs at the company move in and out of jobs, and new ones from the outside move in.

Perhaps the most important change to occur is the replacement this week of SVP Scott Dietzen–who has been in charge of all communications and communities products at Yahoo (YHOO)–by former Adobe Systems (ADBE) exec Bryan Lamkin, several sources said.

Lamkin will become SVP of Applications Products.

According to his profile on LinkedIn, Lamkin (pictured here) was most recently SVP of Creative Solutions, Adobe’s largest business unit, where the software exec “led product strategy, marketing and product development for Adobe’s flagship software applications, including Photoshop, the Creative Suite, Dreamweaver, Flash and Illustrator.”

Lamkin, who was at Adobe for 14 years, has more recently been an executive-in-residence at two venture firms, New Enterprise Associates and Sutter Hill Ventures.

He will take over for Dietzen, who came to Yahoo in 2007 after its $350 million Zimbra open-source email acquisition

Dietzen–whom sources said is more entrepreneurial than managerial and did not want to lead such a big organization at the Internet giant–will become VP of strategy in the move. Many said they expect he will eventually leave Yahoo to try his hand at another start-up.

His colleague, Zimbra founder and CEO Satish Dharmaraj, left Yahoo earlier this year to join Redpoint Ventures as a VC.

In his job since, Dietzen has been busy fixing Yahoo’s mail and calendar offerings. (See my video interview with him below from last fall.)

But that’s not all.

Also afoot is a restructuring of Yahoo’s North American sales unit, with the unexpected promotion of Mitch Spolan, who was a regional sales exec and will now be in charge of all North American field sales.

The paidContent Web site reported the sales changes first, which have been rumored around Yahoo recently.

Spolan jumped over two more senior execs, sources said, who run sales operations for the East and West coasts. One of those execs, Beth Lawrence, will now run Yahoo’s relations with agencies. Both report to U.S. sales SVP Joanne Bradford.

Over the last 18 months, Yahoo has seen a bleeding of its advertising staff to a wide range of Silicon Valley Web companies, including, most recently, Yahoo’s VP of Sales Operations Dan Foehner to social-networking site Facebook.

Lastly, one of Yahoo’s most senior communications execs, Brad Williams, was let go as part of its recent round of layoffs. He had been running PR–admirably and with good cheer, I might add, despite all the bad news–since its head, Jill Nash, departed earlier this year.

Williams’s departure was first reported by The Wall Street Journal tonight. He came to Yahoo in early 2008 from eBay (EBAY).

New marketing head Elisa Steele, who was hired by CEO Carol Bartz, had recently hired a headhunting firm to find a new PR chief, sources said, and Williams was not considered as a candidate for the job.

UPDATE: Yahoo confirmed my report above.

A spokesman sent me the following info about Lamkin’s appointment:

Bryan Lamkin, formerly of Adobe, is joining Yahoo! as senior vice president of Applications Products, reporting directly to Ari Balogh. As a reminder, the Applications Products group consists of several key global products for Yahoo!, including Yahoo! Mail, Yahoo! Messenger, Flickr, Yahoo! Answers, Yahoo! Groups and Zimbra.

Bryan brings a wealth of experience on the consumer technology front and his background ties in nicely with Yahoo!’s ongoing focus to deliver great consumer experiences across the globe.

Bryan takes over for Scott Dietzen, who was named the interim head of Application Products following the reorg back in February. Scott will continue on at Yahoo!, and will work across Yahoo!’s Applications Products in a new product strategy role.

Bio

Bryan Lamkin

Senior Vice President, Applications Product, Yahoo!

Bryan Lamkin joins Yahoo! as the senior vice president of Applications Products. In this role, he will oversee the global strategy, development and performance for key products within the Yahoo! portfolio, including Yahoo! Mail, Yahoo! Messenger, Flickr, Yahoo! Answers, Yahoo! Groups and Zimbra.

Lamkin most recently served as senior vice president and general manager of Creative Solutions, Adobe’s largest business unit. Lamkin led product strategy, marketing and research and development for Adobe’s flagship software applications, including the Photoshop, Photoshop Elements, the Creative Suite, Dreamweaver, Flash and Illustrator.

In his 14 years at Adobe Systems, Lamkin held key management positions including Senior Vice President and General Manager, Digital Imaging and Video and Vice President of Marketing, Professional Publishing Solutions. Lamkin was responsible for product development and marketing as well as the acquisition and product integration strategies that established Adobe’s overwhelming leadership in digital imaging and video and web publishing. Before joining Adobe Systems, Lamkin served in key product marketing and international product development roles at Software Publishing Corporation and holds both a BA and MBA from the University of California at Berkeley.

And here is Dietzen in my video interview:

Here’s a video of star VC John Doerr reciting his 10 tips for start-ups to follow in the economic downturn.

Doerr gave out the advice at VentureBeat’s “How to manage your start-up in the downturn” roundtable event, which took place at the Stanford Park Hotel in Palo Alto yesterday morning.

The Kleiner Perkins Caufield & Byers VC got a lot of attention for his list, which he culled from a survey of 18 of the companies his firm has invested in.

Doerr didn’t need a massive, noisy PowerPoint like Sequoia Capital to make his quick and clear points, which he delivered in four minutes flat.

Doerr was on an investors panel with Ram Shriram, one of Google’s first investors, Ron Conway, Kittu Kolluri of New Enterprise Associates and Matt Cohler of Benchmark Capital.

I moderated the second panel of entrepreneurs, including: Toni Schneider, chief executive of Automattic, the company that makes the WordPress blogging software; Max Levchin of Slide, Jason Calacanis of Mahalo; and Nirav Tolia of Web 1.0’s Epinions. Video of interviews with them and also Shriram to come later today!

But here’s Doerr reciting his 10 tips:

It will take place at the Stanford Park Hotel in Palo Alto from 8 a.m. to noon.

Toni Schneider, chief executive of Automattic (the company that makes the WordPress blogging software) will join Max Levchin of Slide, Jason Calacanis of Mahalo, O’Melveny & Myers’ Sam Zucker, and Nirav Tolia of Web 1.0’s Epinions.

Along with my group, for whom I am planning all sorts of verbal tortures (”Exactly how much do you make?”), there is also a panel of investors, moderated by VentureBeat’s Matt Marshall, which features: John Doerr of Kleiner Perkins Caufield & Byers; Ram Shriram, one of Google’s first investors, Ron Conway, Kittu Kolluri of New Enterprise Associates and Matt Cohler of Benchmark Capital.

Oh, it is sure to be a festival of Web 2.0 pondering.

Said Marshall in a post about the gathering:

One goal of this event is to provide context and advice for start-up CEOs and founders facing the recession. We’ve handpicked the speakers for their remarkable records and experiences in the previous downturn. …

While the Sequoia [Capital] ‘RIP Good Times’ presentation gave a broad overview of the economic problems facing the tech world, it provided mostly a macro analysis, and a general prescription for companies.

Now is the time to take the analysis one step further, and discuss the variety of situations we see among valley investors and their start-ups: How cleantech companies are different from Internet start-ups, and how under certain conditions, a profitable company may actually be poised for aggressive growth, hiring and M&A–and not necessarily ideal for cost cutting. We intend to explore all of this and more.

Given the fairly predictable ‘Silicon Valley is in circle-the-wagons mode’ story line we’ve been seeing so far in the media, this event is also the Valley’s opportunity to help dispel this myth and explain how the area’s start-ups are actually quite diverse and that there are a mix of strategies at play.”

The event is sold out, but it will be streamed live.

And, as usual, look for a shaky video report of the roundtable from me later!

In a move to dramatically increase its traffic and give it more tools to offer publishers, Clearspring Technologies said it will acquire AddThis, the top bookmarking and content-sharing tool on the Web.

As with many social-networking start-ups, whether this disparate traffic can be easily translated into a reliable revenue-generating business remains to be seen.

The McLean, Va.-based Clearspring–one of several widget networks seeking to connect publishers and advertisers with social tools by helping them embed small pieces of content across the Web and monetize that content–would not disclose the price it paid for the Princeton, N.J.-based AddThis.

My guess: A few million dollars in cash and maybe more in some kind of stock swap.

What exactly is Clearspring getting for this?

For starters, a tiny icon with a lot of popularity to help it toward its goal of being the universal sharing standard in the new socially-networked Web paradigm.

Clearspring claims the pair together will reach 20 billion views per month and more than 200 million unique visitors, noting it would now have a “worldwide audience comparable to the seventh largest Web property.”

While adding up such piecemeal traffic is not quite the same to advertisers as a major central Web site like Yahoo (YHOO), for example, AddThis is the most used tool for sharing Web pages through email or from Web site to Web site.

Its main competitors are ShareThis and Yahoo’s Del.icio.us, even though it has only a handful of employees.

Of course, that viral success around universal sharing might not mean massive revenue generation, even if it is a popular consumer tool.

But Ted Leonsis, chairman of the board at Clearspring, and CEO Hooman Radfar said revenue would come via advertising and, eventually, valuable data analytics the services collect about Web behavior.

Currently, said Leonsis, AddThis has negligible revenue and Clearspring has about $10 million in annual sales. Neither is currently profitable.

Nonetheless, Radfar said, “AddThis is the biggest small thing on the Web,” referring to its tiny icon that expands to offer users a choice of Internet sharing services and updating tools to a variety of social networks.

And indeed, AddThis icons are widespread across the Web, seen mostly at the bottom of content items on big sites like Time.com and MySpace.

While some question whether a big business can be created through such a far-flung network, Leonsis–one of the early execs at AOL in its glory days–said it was how the Web is evolving.

“If you said to me 10 years ago that you were going to be successful by sending people away from your site, I would have said you were crazy,” said Leonsis. “But that is what the Web is about now, and having a central network that can track this is important for advertisers.”

Well, we’ll see about that, but Clearspring certainly has a lot of money to try.

The company has received more than $35 million in funding since it was founded in 2004. Investors include former AOL head Steve Case, as well as the venture firm New Enterprise Associates.

Clearspring has about 100 employees.