Yahoo CEO Carol Bartz is making the most substantive changes in her exec ranks since she did a massive restructuring of its staff in late February, according to sources close to the situation.

“She is continuing to clean the place up,” said one top exec about the moves, which are likely to be announced internally tomorrow.

Will these changes also extend to Yahoo’s board?

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Yahoo’s SVP of Northern American Audience, Jeff Dossett, is leaving the company.

Reasons for the departure are personal, said sources, who said that Dossett is most likely to do a start-up.

Dossett did not return emails asking for comment, but Yahoo confirmed his resignation to BoomTown.

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Neeraj Khemlani, Yahoo’s general manager and executive editor of news, is set to leave his job–right in the midst of a major restructuring of its media unit–to work at Hearst Corp.

Khemlani’s departure could be announced to his staff at Yahoo as early as today.

While Khemlani was in line to head one of the three main prongs of the new content organization, running a possible network programming arm, sources inside and outside Yahoo said he instead has opted to take a job as VP and Special Assistant to the CEO for Digital Media at Hearst.

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Besides the more massive management reorganization that new Yahoo CEO Carol Bartz could announce this week, as BoomTown reported on Friday, the Internet company’s powerful media arm might also see a drastic shift in management structure even sooner.

According to several sources inside the company, U.S. Audience SVP Jeff Dossett has been working on the changes for a while, part of an overall change in how Yahoo makes and delivers content.

Under a plan being considered, the media unit will be split into three parts: vertical programming, network programming and search monetization.

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