Former Facebook exec Owen Van Natta will take the CEO job at a music discovery site called Playlist, a move that had been speculated last week, after he did not end up taking another position as head of MySpace Music.

Van Natta’s arrival at Playlist was not the only news for the Palo Alto, Calif.-based start-up–former AOL exec Bob Pittman’s Pilot Investment Group is also investing an undisclosed amount of money in Playlist. Pittman will also join its board.

Playlist has previously raised several million dollars, said sources, but the new funding is many times that, to total about $18 to $20 million.

The move to Playlist is an interesting one for Van Natta, who has looked at a number of jobs since leaving the high-profile social-networking site earlier this year.

He has talked to a wide range of companies, sources said, including Microsoft (MSFT) and a range of start-ups, as well as with MySpace, which is owned by News Corp. (NWS). (News Corp. also owns this site).

Those talks between Van Natta and MySpace to run its new music initiative did not pan out for a variety of reasons.

But he has long expressed a desire to become a CEO of a company, rather than just head to another executive job within a larger company, so the move to run a start-up is not a surprise.

In an interview this afternoon, Van Natta told me he got very intrigued by the possibilities at Project Playlist, which was the first iteration of the start-up and in which he is an investor, due to its viral growth.

And, indeed, Playlist has grown quickly to become one of the larger music communities on the Web, claiming that more than 38 million music fans monthly, sharing playlists via its Web site and also widely distributed embeddable widgets. The site has tens of millions of daily page views, according to surveys.

To get to those big-scale numbers, Playlist essentially has offered users a giant linking service for music, not unlike Google (GOOG) with all information, pointing users to promotional, free and sometimes illegal music and music video tracks all over the Web.

Those links to illegal music have resulted in a lawsuit aimed at Playlist from the music industry, sources said, a sadly typical experience of many online music services.

The usual tactic for the music giants: Sue first and shake down later.

Under Van Natta, I would guess, Playlist is likely to reach out to music companies and strike deals.

The company also needs to settle on its main business plan, which appears to me to have been less important than its explosive growth.

Playlist currently does have some small amount of advertising on the site, and seems to be making most of its scratch from sending leads to ringtone sellers.

Van Natta did not want to reveal specific strategies for Playlist going forward, only noting the opportunity is large.

“Discovery around music is exploding on the Internet,” said Van Natta. “And the company that does the best job of taking advantage of that is really going to be huge.”

That said, there have been a lot of music-aimed efforts like Playlist in the music space, with a lot of different business plans and varying degrees of success, ranging from the Apple (AAPL) behemoth iTunes site, which sells single songs, to the CBS (CBS) music service, Last.fm, which relies more on advertising revenues.

Other contenders in the space include the Rhapsody subscription service from RealNetworks (RNWK), music discovery service iLike and many others. MySpace has also waded deeply into the music space, and Facebook is also reportedly weighing its own service.

Van Natta was one of Facebook’s earliest and most prominent execs, serving in jobs like COO and also Chief Revenue Officer while there.

He came to Facebook in the fall of 2005, after a stint as VP of Worldwide Business and Corporate Development at Amazon, and was part of the founding team of A9, the Amazon search company.

“I am excited to be building a company again,” said Van Natta, who has taken many months off since he left Facebook in February.

But–as many readers have requested–they will all be available in their entirety over the next weeks in this column.

Here’s Part 3 of 4 of an interview Walt Mossberg did with the Gates Foundation’s Melinda Gates.

(I will be posting one video part of the discussion with Melinda Gates every day this week through Thursday.)

As you will see, Melinda Gates is articulate in ways that are critical to the task that she and her husband–that would be Microsoft (MSFT) Founder Bill Gates–have put before themselves: Big league philanthropy with deeply effective results, specifically in health and learning.

In this video, Melinda Gates talks about the best ways to fix the broken parts of the public high school educational system in the U.S.

Though I jokingly congratulated Calacanis on the investment from a “toddler VC,” because of the 33-year-old Botha’s freshly-scrubbed and youthful looks, I’d be pretty pleased if my two sons–2 and 5 years old–could be involved in a multibillion deal after only a few years on the job.

“You have to put yourself in a position to be lucky,” said the South African-born Botha over lunch at the Sundeck on Sand Hill Road in Silicon Valley recently.

Here’s a video I did of my visit with Botha, where I both incorrectly note the address of Sequoia and willfully refuse any effort at pronouncing his name with any grace:

Botha, who is the clear protege of Silicon Valley uber-VC Mike Moritz of Sequoia (of Yahoo and Google fame), seems to be awfully good at that, after scoring a big win for the firm when he turned a $12 million investment in YouTube into a $450 million windfall after the online video site was sold last year to Google for $1.65 billion.

Botha’s previous stint at PayPal (where he met the team that later put together YouTube), a job he got to earn money while at Stanford Business School, ended with him being CFO at the time of its 2002 IPO. It was soon sold for another $1.5 billion to eBay.

His background is actually more in math, with his first job as an actuary. Botha later became a consultant, before he came to Silicon Valley to get his MBA from Stanford.

While many mistakenly think he is related to former hard-line South African Prime Minister P.W. Botha, he actually is the grandson of a well-known former foreign minister Pik Botha, a liberal politician at a time of not-very-liberal policies related to apartheid.

He arrived at Sequoia after PayPal, although he noted that he had no experience in being a VC, and he has been intent on finding companies that “solve consumer problems.”

Currently, he is invested in another online video start-up, the high-profile Joost, as well as instant-messaging site Meebo and shoe and accessory online retailer Zappos.com.

He is also foraging around in the world of “bioinformatics,” which he thinks is a promising new arena marrying Web and medical technologies.